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Fig. 7 | Journal for ImmunoTherapy of Cancer

Fig. 7

From: miR-448 targets IDO1 and regulates CD8+ T cell response in human colon cancer

Fig. 7

A possible negative feedback loop to regulate CD8+ T cell activation. Upregulation of IDO1 occurs in tumors in response to IFN-γ, which is secreted by activated CD8+ T cells, while the expression of IDO1 is increased, CD8+ T cell response will be suppressed, resulting in tumor immune evasion and tumor growth. However, miR-448 downregulates IDO1 protein expression, and the feedback of IDO1 to CD8+ T cells will be impaired. Thus, the number of CD8+ T cells in the tumor microenvironment will be increased, resulting in tumor rejection

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