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Fig. 4 | Journal for ImmunoTherapy of Cancer

Fig. 4

From: Antibody targeting tumor-derived soluble NKG2D ligand sMIC provides dual co-stimulation of CD8 T cells and enables sMIC+ tumors respond to PD1/PD-L1 blockade therapy

Fig. 4

Combination therapy of anti-PD-L1 antibody and sMIC-targeting mAb B10G5 cooperatively increase DC activation (CD40) and the expression of co-stimulatory molecules CD80 and CD86 in tumor sites. a, Representative histograms from flow cytometry analyses of CD40, CD80 and CD86 expression on DCs from tumor-draining lymph nodes and tumor beds. Gray filled profiles, control isotype staining. Open dark profiles, antibody to specific DC surface molecules. b, Summary data of the increase in mean fluorescence intensity (MFI) of CD80, CD86, and CD40 on DCs

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