Skip to main content
Fig. 5 | Journal for ImmunoTherapy of Cancer

Fig. 5

From: Antibody targeting tumor-derived soluble NKG2D ligand sMIC provides dual co-stimulation of CD8 T cells and enables sMIC+ tumors respond to PD1/PD-L1 blockade therapy

Fig. 5

Targeting sMIC increases co-stimulatory molecules on CD8 T cells in tumor draining LN and tumor infiltrates. a and b, Representative histograms (a) and summary data (b) demonstrating NKG2D expression on CD8 T cells. c and d, Representative histogram overlay (c) and summary data of mean fluorescence intensity (MFI) (d) demonstrating CD28 expression on CD8 T cells. Grey profiles in (c) are CD28 expression in CD8 T cells from cIgG treated animals. Black profiles in (c) are CD28 expression in CD8 T cells from animals receiving respective therapy

Back to article page