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Fig. 6 | Journal for ImmunoTherapy of Cancer

Fig. 6

From: Antibody targeting tumor-derived soluble NKG2D ligand sMIC provides dual co-stimulation of CD8 T cells and enables sMIC+ tumors respond to PD1/PD-L1 blockade therapy

Fig. 6

sMIC-targeting antibody and a CD28 agonist antibody provides CD8 TCR with dual co-stimulation and thus optimal and sustained activation. a, SV40TAg-specific TCR-I CD8 T cells were stimulated with the indicated conditions and evaluated for intracellular IFNγ production after 24 h of stimulation. b, Cells were stimulated with indicated conditions for three and 5 days. Expression of the TCR/CD3 signaling molecule CD3ζ was assessed by flow cytometry analyses with intracellular staining. c and d, Representative summary data of (a) and (b) respectively. Data represent results of triplicates of four independent experiments

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