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Fig. 7 | Journal for ImmunoTherapy of Cancer

Fig. 7

From: Antibody targeting tumor-derived soluble NKG2D ligand sMIC provides dual co-stimulation of CD8 T cells and enables sMIC+ tumors respond to PD1/PD-L1 blockade therapy

Fig. 7

Antibody cocktail therapy of sMIC-targeting mAb B10G5 and anti-PD-L1 antibody cooperatively enriched NK cell infiltration and enhanced NK cell function in tumors. a and b, Representative dot plots (a) and summary data (b) from all animals present that antibody cocktail therapy significantly enriched NK cell in tumor infiltrates compared with monotherapy. b and d, Representative histograms (b) and summary data (d) from all animals present that antibody cocktail therapy significantly enhanced NK cell responsiveness in tumors compared with monotherapy. Note that anti-PD-L1 antibody monotherapy presented no significant effect on NK cells. TIL, tumor infiltrated lymphocytes. ns, not significant

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