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Fig. 8 | Journal for ImmunoTherapy of Cancer

Fig. 8

From: Antibody targeting tumor-derived soluble NKG2D ligand sMIC provides dual co-stimulation of CD8 T cells and enables sMIC+ tumors respond to PD1/PD-L1 blockade therapy

Fig. 8

Anti-sMIC therapy with B10G5 up-regulates PD-L1 expression on tumor cells, which is in part NK cell dependent. a, Depletion of NK cells (dpNK) during therapy diminishes the therapeutic effect of co-targeting sMIC and PD-L1 as assessed by prostate weight at necropsy. All treatments were given twice weekly i.p. for 8 weeks. b, Representative histograms from flow cytometry analyses demonstrating the percentage of PD-L1+ tumor cells from TRAMP/MICB mice. c, Summary data of the percentage of PD-L1+ tumor cells from (a)

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