Table 2 Univariate and Multivariable Cox Proportional Hazard Models of PFS vs BMI

Univariate Model

Overweight (vs Normal BMI)

1.1(0.67,1.83)

0.7

1.58(0.78,3.19)

0.21

0.36(0.15,0.85)

0.02

Obesity (vs Normal BMI)

0.98(0.59,1.63)

0.93

1.49(0.71,3.13)

0.3

0.17(0.04,0.65)

0.01

Multivariable Model

Overweight (vs Normal BMI)

0.97(0.56,1.69)

0.92

2.34(1.05,5.2)

0.04

0.5(0.15,1.71)

0.27

Obesity (vs Normal BMI)

1.16(0.7,1.94)

0.57

2.46(1.03,5.89)

0.04

0.18(0.05,0.74)

0.02

Female

0.94(0.59,1.51)

0.81

1.05(0.6,1.84)

0.85

1.8(0.72,4.49)

0.21

Age at Treatment Initiation

1(0.98,1.01)

0.77

0.99(0.97,1.01)

0.28

0.99(0.95,1.03)

0.67

Stage IV at Treatment Initiation(vs Stage III)

3(1.07,8.41)

0.04

0.88(0.3,2.64)

0.82

0.19(0.02,1.62)

0.13

ECOG Status

1.78(1.22,2.6)

0.003

2.67(1.65,4.31)

0.003

3.02(1.44,6.32)

<.001

LDH High

1.16(0.74,1.82)

0.52

2.25(1.08,4.7)

0.03

1.45(0.65,3.23)

0.36

Number of Metastatic Sites

1.21(1.04,1.4)

0.02

1.11(0.91,1.36)

0.29

0.94(0.7,1.25)

0.68

BRAF Mutated

0.86(0.37,2)

0.73

0.43(0.12,1.6)

0.21

1.83(0.61,5.54)

0.28