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Fig. 4 | Journal for ImmunoTherapy of Cancer

Fig. 4

From: PD-L1 blockade engages tumor-infiltrating lymphocytes to co-express targetable activating and inhibitory receptors

Fig. 4

Diffusion maps of the identified CD4+ and CD8+ subsets in the control and treated group. (a) Two-dimensional diffusion map of the CD4+ and CD8+ T cells present in the tumor at day 8 after the first PD-L1 treatment. Three different CD4+ and CD8+ T cell metaclusters have been identified by PhenoGraph. Continuity of the pattern reveals relationship between the different represented metaclusters (n = 5 mice per group). (b) Diffusion map of the CD4+ and CD8+ TAI cell displayed by group origin (PBS in blue and PD-L1 in red). (c) Diffusion map of the CD4+ and CD8+ TAI cell displayed by marker expression ICOS, LAG-3, CD39, PD-1 and CD69. (d) Expression levels of CD44 and CD62L on the metaclustered CD4+ and CD8+T cell populations. (e) Expression levels of ICOS, LAG-3, CD39, PD-1 and CD69 on the metaclustered CD4+ and CD8+T cell populations

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