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Fig. 7 | Journal for ImmunoTherapy of Cancer

Fig. 7

From: PD-L1 blockade engages tumor-infiltrating lymphocytes to co-express targetable activating and inhibitory receptors

Fig. 7

Identification of the TAI cell subset in humans. (a) Heatmap of CD8+ T-cell phenotypes (pre-gated on CD45+ CD3+ CD4− cells) in tumors of 5 human colorectal cancer (MMRd) patients. Dendrogram above shows the hierarchical similarity between the identified clusters. Right panel shows the frequency of CD8+ LAG3+ ICOS+ cells (cluster 8) among total CD8+ T cells across the 5 patients. (b) Gating strategy to identify the CD4+ CD69+ PD1+ CD39+ ICOS+ population in human colorectal cancer. The abundance proportional to circle area is shown

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