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Table 2 Univariate and multivariate analysis of overall survival factors.

From: A PD-L2-based immune marker signature helps to predict survival in resected pancreatic ductal adenocarcinoma

  N Overall survival
Univariable analysis Multivariable analysis
HR (95% CI) P HR (95% CI) P
All 305     
Age (years)   0.588   
 <60 106 Ref    
 ≥60 199 0.929 (0.711-1.213)   
Sex   0.916   
 Male 158 Ref    
 Female 147 1.007 (0.888-1.142)   
T stage   < 0.001   < 0.001
 T1-2 227 Ref   Ref  
 T3 78 1.744 (1.333-2.361) 2.065 (1.542-2.767)
N stage   < 0.001   < 0.001
 N0-1 262 Ref   Ref  
 N2 43 2.487 (1.754-3.526) 3.049 (2.127-4.373)
AJCC stage   < 0.001   < 0.001
 I-II 262 Ref   Ref  
 III 43 2.487 (1.754-3.526) 3.049 (2.127-4.373)
Grade   0.001   < 0.001
 Well and moderate differentiation 191 Ref   Ref  
 Low differentiation 114 1.536 (1.187-1.989) 1.632 (1.255-2.124)
Intratumoral PD-L2   < 0.001   < 0.001
 Low expression 238 Ref   Ref  
 High expression 67 1.858 (1.387-2.487) 1.892 (1.402-2.552)
Intratumoral CD3   0.07   0.003
 Low cell densities 220 Ref   Ref  
 High cell densities 85 0.768 (0.577-1.022) 0.646 (0.482-0.865)
Stromal CD3   0.053   0.041
 Low cell densities 119 Ref   Ref  
 High cell densities 186 1.295 (0.997-1.683) 1.319 (1.012-1.721)
Intratumoral CD8   0.143   
 Low cell densities 260 Ref    
 High cell densities 45 1.292 (0.917-1.821)   
Stromal CD8   0.066   0.372
 Low cell densities 272 Ref   Ref  
 High cell densities 33 0.663 (0.427-1.028) 0.814 (0.517-1.279)
Intratumoral FOXP3   0.006   0.002
 Low cell densities 257 Ref   Ref  
 High cell densities 48 1.580 (1.138-2.193) 1.704 (1.215-2.389)
Stromal FOXP3   0.008   0.132
 Low cell densities 292 Ref   Ref  
 High cell densities 13 2.157 (1.227-3.790) 1.647 (0.860-3.153)
Risk score   < 0.001   < 0.001
 Low score 228 Ref   Ref
 High score 77 2.047 (1.549-2.706) 1.836 (1.379-2.444)