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Fig. 2 | Journal for ImmunoTherapy of Cancer

Fig. 2

From: Combination immunotherapy and radiotherapy causes an abscopal treatment response in a mouse model of castration resistant prostate cancer

Fig. 2

Monotherapy is similar to no treatment, and tumor cell proliferation and apoptosis is minimally effected. a. Myc-CaP tumor graft volumes for untreated mice and those treated with immune checkpoint inhibitor monotherapy. b. Survival of mice with Myc-CaP grafts, including no treatment, XRT alone, and immune checkpoint inhibitor monotherapy, as indicated, with no significant differences in median overall survival between the groups (log-rank test, p > 0.05). c and d. Ki67 and cleaved caspase-3 (Casp3) immunohistochemical staining analyzed by whole slide digital imaging. Independent graft numbers analyzed: anti-PD-1 (N = 4), anti-PD-L1 (N = 6), anti-PD-1 + XRT leg graft (N = 4), anti-PD-L1 + XRT leg graft (N = 2), anti-PD-1 + XRT flank unirradiated graft (N = 3), anti-PD-L1 + XRT flank unirradiated graft (N = 3). Error bars represent ± SEM

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