Fig. 6
From: Discovery of low-molecular weight anti-PD-L1 peptides for cancer immunotherapy
Anti-tumor activity of the anti-PD-L1 peptides and antibody. a CT26 tumor-bearing Balb/C mice (n = 10, 5 male and 5 female) were intraperitoneally injected with the anti-PD-L1 peptides (2 mg/Kg) daily for a total of 10 injections and the anti-mouse PD-L1 antibody (10 mg/Kg) every other day for a total of 5 injections. b Tumor volume measured over time. Tumor volume results were represented as the mean ± SE (n = 10). c Tumor growth curves of individual mice in each group. Image d and weight e of tumors harvested at day 14. The results were represented as the mean ± SD (n = 10). The expressions of IFNγ f, PD-L1 g and IL-6 h in harvested tumors were measured using ELISA. i The numbers of CD8+ T cells in each specimen were quantitated after immunohistochemical staining. Results were represented as the mean ± SD (n = 4). j Representative images of tumor specimen stained with anti-CD8 antibody. The scale bar represents 200 μm. (* p < 0.05; ** p < 0.01; *** p < 0.001)