Fig. 4

Landscape shows the immune signature of body fluid in each molecular subtype of primary tissue. Patients were categorized by The Cancer Genome Atlas (TCGA) molecular subtype which was composed of Epstein Barr Virus (EBV) positive, microsatellite instability (MSI), genomically stable (GS)-like and chromosomal instability (CIN)-like. Diffuse type and intestinal type by Lauren classification were filled with yellow and green, respectively. Molecular markers by histochemistry were classified with positive (red) or negative (orange). Continuous value of cytokine and immune cell proportion were dichotomized by best-cut off which calculates the maximizing hazard ratio (HR) based on log-rank statistics (low vs. high). Low value was filled with blue while high value was filled with pink. * Cytokine model was scored by a number of high levels of VEGF-A, IL-10 and TGF-β1, and it was categorized 0–1 (low group) and 2–3 (high group). TCGA, The Cancer Genome Atlas; EBV, Epstein-Barr virus; MSI-H, microsatellite instability-high; CIN, chromosomal instability; GS, genomically stable; VEGF, vascular endothelial growth factor; IL, interleukin; TGF-β1, transforming growth factor- beta1; CD, cluster of differentiation