Fig. 5

VEGF-A and PD-L1 positivity on tumor cell (%) are different between CIN-like and GS-like group, and proportion of T lymphocyte with CD25 is higher in previously chemotherapy treated group than chemotherapy naïve group. a VEGF-A level was significantly higher in GS-like group than that in CIN-like group (median value: 163.9 vs. 17.4 pg/mL, P = 0.003). b PD-L1 (%) of tumor cells showed a higher tendency in CIN-like group than that in GS-like group (median proportion: 0.47 vs. 0.17%, P = 0.08). c-d Proportion of early activated T cells (CD3CD25 and CD4CD25) in previously chemotherapy treated patients was higher level than that in chemotherapy naive patients (P = 0.017 and P = 0.035, respectively). Red line indicates median value. Mann-Whitney U test was used for statistical analysis. *P < 0.05, **P < 0.01