General Disorders and Administration Sites
| | | | | | | |
11 (42)
|
Fatigue
|
1 (25)
|
–
|
1 (33)
|
3 (100)
|
–
|
1 (14)
|
–
| |
Peripheral coldness
|
1 (25)
|
–
|
–
|
–
|
–
|
–
|
–
| |
Pyrexia
|
–
|
–
|
–
|
–
|
–
|
1 (14)
|
–
| |
Chills
|
–
|
–
|
–
|
–
|
–
|
1 (14)
|
–
| |
Edema
|
–
|
–
|
–
|
2 (67)
|
–
|
–
|
–
| |
Skin and Subcutaneous Tissue
| | | | | | | |
9 (35)
|
Erythema
|
–
|
–
|
–
|
1 (33)
|
–
|
–
|
–
| |
Night sweats
|
–
|
–
|
–
|
–
|
–
|
1 (14)
|
–
| |
Pruritus
|
1 (25)
|
1 (20)
|
–
|
–
|
–
|
–
|
–
| |
Rash
|
1 (25)
|
1 (20)
|
1 (33)
|
1 (33)
|
–
|
–
|
–
| |
Urticaria
|
1 (25)
|
–
|
–
|
–
|
–
|
–
|
–
| |
Gastrointestinal
| | | | | | | |
5 (19)
|
Abdominal distension
|
–
|
–
|
–
|
1 (33)
|
–
|
–
|
–
| |
Abdominal Pain
|
–
|
–
|
–
|
2 (67)
|
–
|
–
|
–
| |
Diarrhea
|
1 (25)
|
1 (20)
|
–
|
–
|
–
|
–
|
–
| |
Infections and Infestations
| | | | | | | |
4 (15)
|
Upper Respiratory Tract Infection
|
–
|
1 (20)
|
–
|
–
|
1 (33)
|
1 (14)
|
–
| |
Abscess
|
–
|
–
|
–
|
1 (33)
|
–
|
–
|
–
| |
Musculoskeletal and Connective Tissue
| | | | | | | |
4 (15)
|
Arthralgia
|
–
|
–
|
–
|
1 (33)
|
–
|
–
|
–
| |
Muscular weakness
|
1 (25)
|
–
|
–
|
–
|
–
|
–
|
–
| |
Myalgia
|
1 (25)
|
–
|
–
|
–
|
–
|
–
|
–
| |
Stiffness
|
–
|
1 (20)
|
–
|
–
|
–
|
–
|
–
| |
Nervous System
| | | | | | | |
3 (12)
|
Dizziness
|
–
|
–
|
–
|
1 (33)
|
–
|
–
|
–
| |
Headache
|
–
|
–
|
–
|
–
|
–
|
1 (14)
|
–
| |
Paraesthesia
|
–
|
–
|
–
|
1 (33)
|
–
|
–
|
–
| |
Blood and Lymphatic System
| | | | | | | |
7 (27)
|
Anemia
|
–
|
–
|
–
|
1 (33)
|
1 (33)
|
–
|
–
| |
Neutropenia
|
2 (50)
|
–
|
–
|
1 (33)
|
1 (33)
|
–
|
–
| |
Thrombocytopenia
|
–
|
–
|
–
|
–
|
1 (33)
|
–
|
–
| |
Eye
| | | | | | | |
6 (23)
|
Eye pain
|
1 (25)
|
–
|
–
|
–
|
–
|
1 (14)
|
–
| |
Night blindness
|
1 (25)
|
–
|
–
|
–
|
–
|
–
|
–
| |
Photophobia
|
1 (25)
|
–
|
–
|
–
|
–
|
1 (14)
|
–
| |
Reduced visual acuity
|
1 (25)
|
–
|
–
|
–
|
–
|
–
|
–
| |
Laboratory
|
–
| |
–
| |
–
|
–
|
–
|
2 (8)
|
Increased blood viscosity
| |
–
| |
1 (33)
| |
–
| | |
Decreased platelets
| |
1 (20)
| | | |
–
| | |
Respiratory, Thoracic and Mediastinal
| | | | | | | |
4 (15)
|
Cough
|
–
|
–
|
–
|
–
|
–
|
1 (14)
|
–
| |
Dyspnea
|
–
|
–
|
–
|
1 (33)
|
–
|
1 (14)
|
–
| |
Pulmonary edema
|
–
|
–
|
–
|
–
|
–
|
1 (14)
|
–
| |