Skip to main content

Table 2 Clinical features of the study patients according to use of antibiotic therapy

From: Impact of antibiotic therapy on the development and response to treatment of immune checkpoint inhibitor-mediated diarrhea and colitis

Feature

Antibiotic therapy (n = 569)

No antibiotic therapy (n = 257)

p

IMDC, n (%)

267 (46.9)

167 (65.0)

< 0.001

Mean duration of IMDC symptoms, days (SD)

32 (150)

18 (102)

0.290

Hospitalization, n (%)

168 (62.9)

63 (37.7)

< 0.001

Mean duration of hospitalization, days (SD)

8 (7)

7 (5)

0.143

ICU admission, n (%)

10 (1.8)

1 (0.3)

0.038

Grade of colitis, n (%)

  

0.022

 1

42 (20.7)

32 (27.6)

 

 2

90 (44.3)

60 (51.7)

 

 3

65 (32.0)

19 (16.4)

 

 4

6 (3.0)

5 (4.3)

 

Grade of diarrhea, n (%)

  

0.098

 1

77 (28.8)

52 (31.1)

 

 2

69 (25.8)

51 (30.5)

 

 3

103 (38.3)

61 (36.5)

 

 4

18 (6.7)

3 (1.8)

 

Mean duration of steroid administration, days (SD)

52 (44)

63 (79)

0.147

Infliximab/vedolizumab administration, n (%)

52 (19.5)

31 (18.6)

0.900

Recurrence of IMDC, n (%)

42 (15.4)

41 (24.6)

0.025