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Table 4 Clinical features of the study patients according to use of empiric antibiotic therapy at IMDC onset (No. of patients with IMDC = 434)

From: Impact of antibiotic therapy on the development and response to treatment of immune checkpoint inhibitor-mediated diarrhea and colitis

Feature

Antibiotic therapy at IMDC onset (n = 41)

No antibiotic therapy (n = 393)

p

Immunosuppressive therapy for IMDC, n (%)

41 (100.0)

235 (59.8)

< 0.001

Median duration of IMDC symptoms, days (IQR)

17 (8–32)

8 (3–19)

0.888

Hospitalization, n (%)

41 (100)

190 (48.3)

< 0.001

Median duration of hospitalization, days (IQR)

9 (4–15)

5 (3–8)

0.003

ICU admission, n (%)

3 (7.3)

8 (2.0)

0.076

Grade of colitis, n (%)

0.001

 1

6 (14.6)

68 (24.5)

 

 2

12 (29.3)

138 (49.6)

 

 3

22 (53.7)

62 (22.3)

 

 4

1 (2.4)

10 (3.6)

 

Grade of diarrhea, n (%)

< 0.001

 1

4 (9.8)

125 (31.8)

 

 2

8 (19.5)

112 (28.5)

 

 3

24 (58.5)

140 (35.6)

 

 4

5 (12.2)

16 (4.1)

 

Median duration of steroid administration, days (IQR)

39 (23–64)

45 (23–70)

0.496

Intravenous steroid administration, n (%)

35 (85.4)

112 (50.2)

< 0.001

Infliximab/vedolizumab administration, n (%)

18 (43.9)

65 (16.5)

< 0.001

Recurrence of IMDC, n (%)

13 (31.7)

70 (17.8)

0.038

Colon perforation, n (%)

1 (2.4)

6 (1.5)

0.503