Biomaterial-based platforms for in situ dendritic cell programming and their use in antitumor immunotherapy

Calmeiro, João; Carrascal, Mylène; Gomes, Célia; Falcão, Amílcar; Cruz, Maria Teresa; Neves, Bruno Miguel

doi:10.1186/s40425-019-0716-8

Table 1 Overview of different existing anti-cancer biomaterial-based vaccines for DC recruitment and antigen loading

From: Biomaterial-based platforms for in situ dendritic cell programming and their use in antitumor immunotherapy

Approach	Scaffold biomaterial	Load	Administration	Target/tumor model
Two step	Ethylene-vinyl-acetate (EVA) polymers rods	1st CCL19 2nd Tumor lysate	Coimplantation	E.G7-OVA tumor cells injected mice [61]
Two step	Hydrogel - Thermosensitive monomethoxypoly(ethylene glycol)-co-poly(lactic-co-glycolic acid) copolymer (mPEG-PLGA)	1st - GM-CSF 2nd - Tumor antigens	2 injections (injection of viral or nonviral vectors in a 2nd step)	Murine melanoma model [62]
One step	Poly(lactide-co-glycolide)	GM-CSF, CpG, autologous tumor lysate	Implantation	Human melanoma Phase I clinical trial NCT01753089
	Poly(lactide-co-glycolide)	GM-CSF, CpG, tumor lysate	Implantation	Murine melanoma model [41, 63,64,65,66]
	Poly(lactide-co-glycolide)	GM-CSF, CpG, tumor lysate	Implantation	Murine Lewis lung carcinoma (LLC) [64]
	Poly(lactide-co-glycolide)	GM-CSF, CpG, tumor lysate	Implantation	Rat glioma model [67, 68]
	Poly(lactide-co-glycolide)	GM-CSF, CpG, Tumor lysate	Implantation	Murine melanoma model; combination with anti PD-1 or CTLA-4 mAb [69]
	Poly(lactide-co-glycolide)	CCL20, CpG, tumor lysate	Implantation	Murine melanoma model [66]
	Poly(lactide-co-glycolide)	Flt3L, CpG, tumor lysate	Implantation	Murine melanoma model [66]
	Poly(lactide-co-glycolide)	GM-CSF, MPLA, tumor lysate	Implantation	Murine melanoma model [64]
	Poly(lactide-co-glycolide)	GM-CSF, Poly-I:C, Tumor lysate	Implantation	Murine melanoma model [64]
	Poly(lactide-co-glycolide)	GM-CSF, Poly-I:C, tumor lysate	Implantation	Murine Lewis lung carcinoma (LLC) [64]
	Hydrogel/cryogel–alginate polymer	GM-CSF, CpG, irradiated tumor cells	Injection	Murine breast cancer [70]
	Hydrogel/cryogel–alginate polymer	GM-CSF, CpG, irradiated tumor cells	Injection	Murine melanoma model [71]
	Covalent and ionic crosslinked cryogel–alginate polymer	GM-CSF, CpG, irradiated -tumor cells	Injection	Murine breast cancer [72]
	Crosslinking hydrogel- dextran vinylsulfone and tetra-thiolated polyethyleneglycol	CCL20 + PLGA microparticles encapsulating IL-10, siRNA and DNA antigen	Injection	Murine A20 B cell lymphoma [73]
	Mesoporous silica rods (MSRs) - synthetic amorphous silica	GM-CSF, CpG, OVA	Injection	Prophylactic action in a murine model, injected with EG7-OVA lymphoma cells [74]

Back to article page