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Fig. 1 | Journal for ImmunoTherapy of Cancer

Fig. 1

From: Adenosine mediates functional and metabolic suppression of peripheral and tumor-infiltrating CD8+ T cells

Fig. 1

Ado-mediated immunosuppression of T cell function depends on the differentiation stage. a Representative example and b cumulative data showing the Ado-mediated fold change in IFN-γ production in total and in distinct memory CD8+ T cell subsets (TCM, TEM, and TEMRA) stimulated overnight with anti-CD3/anti-CD28-coated beads (n = 12) or CMV−/EBV−/Flu-specific peptides (n = 11). The 25th to 75th percentiles, the median and min-max of the values are presented. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001. Wilcoxon and one-way ANOVA tests. c Representative example and d cumulative data of the virus-specific CD8+ T cell functional avidity measured in the presence or absence of Ado in total (n = 12) and in distinct memory CD8+ T cell subsets (TCM, TEM, and TEMRA) (n = 6). Wilcoxon test

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