Fig. 3
From: Clinical and immune profiling for cancer of unknown primary site
Heatmap of immune-related gene expression. CUP cohort (n = 72) was compared with ICI-treated solid cancers (Prat cohort, n = 63). The Prat cohort is divided into PD (n = 29) and non-PD (n = 34) subsets according to the best response to ICI treatment. Each colored square in the heatmap represents the Z score for the expression of one gene, with the highest expression shown in red, median in black, and lowest in green. Clinical characteristics are shown above the heatmap, gene clusters related to specific immune cell types on the right, and the expression of selected genes of interest below. Protein expression evaluated by IHC is shown at the bottom, with red and green boxes representing ≥1 and < 1% for PD-L1 TPS, and with red, green, and gray boxes representing ≥median, <median, and not examined for TIL density (because only a cell block specimen with no tissue on the slide was available), respectively. Treg, regulatory T cell; TAM, tumor-associated macrophage