Table 1 Characteristics of the study patients (n = 164)
From: Clinical and immune profiling for cancer of unknown primary site
Characteristic | No. of patients (%)a | P valueb | |
|---|---|---|---|
Full-analysis set (n = 164) | Biomarker-analysis set (n = 92) | ||
Median age (range), years | 68 (35–95) | 68 (35–95) | 0.915 |
Sex | 0.427 | ||
 Male | 94 (57) | 58 (63) |  |
 Female | 70 (43) | 34 (37) |  |
ECOG performance status | 0.909 | ||
 0–1 | 100 (61) | 57 (62) |  |
 2 | 34 (21) | 17 (18) |  |
 3–4 | 15 (9) | 9 (10) |  |
 Unknown (not recorded) | 15 (9) | 9 (10) |  |
Smoking historyc | 0.772 | ||
 Current or former | 93 (57) | 57 (62) |  |
 Never | 49 (30) | 27 (29) |  |
 Unknown (not recorded) | 22 (13) | 8 (9) |  |
Favorable subset | 34 (21) | 20 (22) | 0.874 |
 Neuroendocrine carcinoma (NEC) | 9 (5) | 4 (4) |  |
 Squamous carcinoma limited to cervical lymph nodes (HNC-like) | 13 (8) | 10 (11) |  |
 Adenocarcinoma restricted to axillary lymph nodes in females (BC-like) | 1 (1) | 1 (1) |  |
 Extragonadal germ cell tumor syndrome (GCT-like) | 1 (1) | 1 (1) |  |
 Peritoneal carcinomatosis in females (PPC-like) | 7 (4) | 2 (2) |  |
 Squamous carcinoma limited to inguinal lymph nodes (ACC-like) | 1 (1) |  |  |
 Single resectable metastatic carcinoma | 2 (1) | 2 (2) |  |
 Unfavorable subset | 130 (79)d | 72 (78)d |  |
Histology | 0.759 | ||
 Squamous | 33 (20) | 21 (23) |  |
 Adeno | 76 (46) | 42 (46) |  |
 Undifferentiated | 36 (22) | 22 (24) |  |
 Other | 19 (12)e | 7 (8)f |  |