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Fig. 1 | Journal for ImmunoTherapy of Cancer

Fig. 1

From: Tumor-infiltrating B cells affect the progression of oropharyngeal squamous cell carcinoma via cell-to-cell interactions with CD8+ T cells

Fig. 1

Differences in frequencies of tumor-infiltrating leucocytes in patients with oropharyngeal squamous cell carcinoma (OPSCC) with respect to the HPV status. a The heat-map expresses z-scores of relative mRNA expression of indicated genes within HPV- (n = 6) and HPV+ (n = 12) tumor samples. Genes with significantly different expression in HPV- and HPV+ tumors are marked in red. b Columns represent the mean (+ standard error of mean, SEM) densities of CD20+ B cells, CD8+ T cells and DC-LAMP+ dendritic cells in tumor nests and tumor stroma of immunohistochemically stained FFPE sections of OPC patients from Cohort 1 (n = 72). c Non-organized CD20+ B cell (brown)/CD8+ T cell (red) aggregate. d CD20+ B cell (brown) – CD8+ T cell interactions. e TLS with germinal center. f Columns show proportions of patients with detected B cell/CD8+ T cell interactions in the tumor nest and the tumor stroma of OPC tissue sections (−, interactions not detected; +, interactions detected in 1–5 visual fields; ++, interactions in > 5 visual fields). * p < 0.05 (Mann-Whitney U test)

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