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Fig. 3 | Journal for ImmunoTherapy of Cancer

Fig. 3

From: Tumor-infiltrating B cells affect the progression of oropharyngeal squamous cell carcinoma via cell-to-cell interactions with CD8+ T cells

Fig. 3

Positive correlation of direct CD20+ B cell/CD8+ T cell interactions with HPV16 E6/E7-specific CD8+ T cells. a Columns show the proportions of patients with low (interactions detectable in 0–5 visual fields) and high (interactions detectable in > 5 visual fields) densities of B cell/CD8+ T cell interactions with respect to the presence or absence of tumor-infiltrating HPV16 E6/E7-specific CD8+ T cells. b Columns represent the mean (+ SEM) proportions of tumor-infiltrating HPV16 E6/E7-specific CD8+ T cells with respect to the densities of B cell/CD8+ T cell interactions within the tumor nests. c Columns represent the mean (+ SEM) densities of CD20+ B cells, CD8+ T cells and DC-LAMP+ dendritic cells in tumor nests and tumor stroma of patients without/with detected HPV16-specific T cells. *, p < 0.05 (Pearson’s chi-square test and Mann-Whitney U test)

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