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Fig. 4 | Journal for ImmunoTherapy of Cancer

Fig. 4

From: Tumor-infiltrating B cells affect the progression of oropharyngeal squamous cell carcinoma via cell-to-cell interactions with CD8+ T cells

Fig. 4

Flow cytometric analysis of tumor-infiltrating B cells and B cells derived from patients’ PBMC divided according to the proportion of TIL-Bs into Blo (% of TIL-Bs < 0.5 of total cells) and Bhi samples. Data are expressed as (a) representative dot plots and (b) mean + SEM of the proportions of B cell subsets within total CD19+ B cells. IgDCD38++, plasma cells; IgDCD38+, germinal center B cells; IgDCD38, memory B cells; IgD+CD38, naive B cells; IgD+CD38+, pre-germinal center B cells. c Columns represent mean + SEM of the MFI of B cell surface markers assessed on total CD19+ B cells. d, e Histograms show a representative expression of indicated B cell surface markers in Blo (upper line) and Bhi (lower line) patient. Gray-filled areas represent isotype-matched controls, red line represents peripheral blood B cells and blue line represents tumor-infiltrating B cells of the same patient. *, p < 0.05; **, p < 0.01 (ANOVA followed by Tukey’s post-hoc test)

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