|
Sex
|
Female
|
1
| | |
|
Male
|
1.14
|
0.37–3.50
|
0.816
|
|
Stage
|
I
|
1
| | |
|
II
|
2.78
|
0.78–9.87
|
0.113
|
|
III
|
3.51
|
0.71–17.4
|
0.124
|
|
IV
|
7.78
|
1.92–31.5
|
0.004
|
|
LN ratio
| |
2.72
|
0.44–16.89
|
0.283
|
|
Extranodal extension
|
No
|
1
| | |
|
Yes
|
6.55
|
2.46–17.41
|
< 0.001
|
|
Perineural spread
|
No
|
1
| | |
|
Yes
|
2.10
|
0.68–6.47
|
0.194
|
|
Resection margin
|
R0
|
1
| | |
|
R1
|
1.56
|
0.57–4.29
|
0.389
|
|
Concomitant chemotherapy
|
No
|
1
| | |
|
Yes
|
1.63
|
0.62–4.28
|
0.323
|
|
Typing SCC
|
NK
|
1
| | |
|
NK-M
|
2.31
|
0.78–6.90
|
0.131
|
|
K
|
5.64
|
1.64–19.41
|
0.006
|
|
Tumor size
| |
1.02
|
1.00–1.06
|
0.042
|
|
HPV status
|
Negative
|
1
| | |
|
Positive
|
0.23
|
0.08–0.66
|
0.006
|
|
Smoking history
|
Non-smoker
|
1
| | |
|
Ex-smoker
|
0.42
|
0.13–1.42
|
0.165
|
|
Smoker
|
0.63
|
0.20–1.91
|
0.412
|
|
TLS
|
No
|
1
| | |
|
Yes
|
1.15
|
0.40–3.27
|
0.789
|
|
CD20+ B cell density tumor nest
| |
0.96
|
0.93–0.99
|
0.015
|
|
CD20+ B cell density tumor stroma
| |
1.00
|
0.99–1.00
|
0.784
|
|
CD8+ T cell density tumor nest
| |
0.99
|
0.99–1.00
|
0.013
|
|
CD8+ T cell density tumor stroma
| |
0.99
|
0.99–1.00
|
0.231
|
|
DC density tumor nest
| |
0.95
|
0.88–1.03
|
0.207
|
|
DC density tumor stroma
| |
0.98
|
0.95–1.02
|
0.328
|
|
B cell/T cell clusters tumor nest
|
-
|
1
| | |
|
+
|
0.35
|
0.13–0.95
|
0.040
|
|
++
|
0.05
|
0.01–0.41
|
0.005
|
|
B cell/T cell clusters tumor stroma
|
-
|
1
| | |
|
+
|
0.07
|
0.01–0.41
|
0.003
|
|
++
|
0.08
|
0.02–0.33
|
< 0.001
|
