Table 2 Prognostic overall survival parameters in univariate analysis

Sex

Female

1

Male

1.14

0.37–3.50

0.816

Stage

I

1

II

2.78

0.78–9.87

0.113

III

3.51

0.71–17.4

0.124

IV

7.78

1.92–31.5

0.004

LN ratio

2.72

0.44–16.89

0.283

Extranodal extension

No

1

Yes

6.55

2.46–17.41

< 0.001

Perineural spread

No

1

Yes

2.10

0.68–6.47

0.194

Resection margin

R0

1

R1

1.56

0.57–4.29

0.389

Concomitant chemotherapy

No

1

Yes

1.63

0.62–4.28

0.323

Typing SCC

NK

1

NK-M

2.31

0.78–6.90

0.131

K

5.64

1.64–19.41

0.006

Tumor size

1.02

1.00–1.06

0.042

HPV status

Negative

1

Positive

0.23

0.08–0.66

0.006

Smoking history

Non-smoker

1

Ex-smoker

0.42

0.13–1.42

0.165

Smoker

0.63

0.20–1.91

0.412

TLS

No

1

Yes

1.15

0.40–3.27

0.789

CD20+ B cell density tumor nest

0.96

0.93–0.99

0.015

CD20+ B cell density tumor stroma

1.00

0.99–1.00

0.784

CD8+ T cell density tumor nest

0.99

0.99–1.00

0.013

CD8+ T cell density tumor stroma

0.99

0.99–1.00

0.231

DC density tumor nest

0.95

0.88–1.03

0.207

DC density tumor stroma

0.98

0.95–1.02

0.328

B cell/T cell clusters tumor nest

-

1

+

0.35

0.13–0.95

0.040

++

0.05

0.01–0.41

0.005

B cell/T cell clusters tumor stroma

-

1

+

0.07

0.01–0.41

0.003

++

0.08

0.02–0.33

< 0.001