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Table 2 Prognostic overall survival parameters in univariate analysis

From: Tumor-infiltrating B cells affect the progression of oropharyngeal squamous cell carcinoma via cell-to-cell interactions with CD8+ T cells

Variable Class Hazard Ratio 95% Confidence Interval P value
Sex Female 1   
Male 1.14 0.37–3.50 0.816
Stage I 1   
II 2.78 0.78–9.87 0.113
III 3.51 0.71–17.4 0.124
IV 7.78 1.92–31.5 0.004
LN ratio   2.72 0.44–16.89 0.283
Extranodal extension No 1   
Yes 6.55 2.46–17.41 < 0.001
Perineural spread No 1   
Yes 2.10 0.68–6.47 0.194
Resection margin R0 1   
R1 1.56 0.57–4.29 0.389
Concomitant chemotherapy No 1   
Yes 1.63 0.62–4.28 0.323
Typing SCC NK 1   
NK-M 2.31 0.78–6.90 0.131
K 5.64 1.64–19.41 0.006
Tumor size   1.02 1.00–1.06 0.042
HPV status Negative 1   
Positive 0.23 0.08–0.66 0.006
Smoking history Non-smoker 1   
Ex-smoker 0.42 0.13–1.42 0.165
Smoker 0.63 0.20–1.91 0.412
TLS No 1   
Yes 1.15 0.40–3.27 0.789
CD20+ B cell density tumor nest   0.96 0.93–0.99 0.015
CD20+ B cell density tumor stroma   1.00 0.99–1.00 0.784
CD8+ T cell density tumor nest   0.99 0.99–1.00 0.013
CD8+ T cell density tumor stroma   0.99 0.99–1.00 0.231
DC density tumor nest   0.95 0.88–1.03 0.207
DC density tumor stroma   0.98 0.95–1.02 0.328
B cell/T cell clusters tumor nest - 1   
+ 0.35 0.13–0.95 0.040
++ 0.05 0.01–0.41 0.005
B cell/T cell clusters tumor stroma - 1   
+ 0.07 0.01–0.41 0.003
++ 0.08 0.02–0.33 < 0.001
  1. Statistically significant P values are printed in boldface. Abbreviations: LN lymph node, SCC squamous cell carcinoma, NK non-keratinizing, K keratinizing, NK-M non-keratinizing with maturation, TLS tertiary lymphoid structures