Fig. 2
From: Unchecked immunity: a unique case of sequential immune-related adverse events with Pembrolizumab
Kidney biopsy showing active tubulointerstitial nephritis ( a ) Interstitial inflammation with moderate numbers of eosinophils, small lymphocytes, and neutrophils [200x]. ( b ) Immunostaining of interstitial lymphocytes showing positivity for T-Cell markers CD4 [200x], and (c) CD8 [200x]. The liver biopsy showing features of autoimmune hepatitis process [200x] ( d ) Portal tract fibrosis with moderate inflammation, periportal hepatocyte ballooning, and focal necrosis. ( e ) Lobular activity with areas of necrosis and inflammation around central vein (black arrows) [200x] ( f ) Confluent necrosis highlighted by PAS stain [100X]. ( g ) Immunostaining of portal and periportal lymphocytes showing positivity for T-Cell markers CD4 [200x], and (H) CD8 [200x]