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Fig. 1 | Journal for ImmunoTherapy of Cancer

Fig. 1

From: Immunoglobulin somatic hypermutation has clinical impact in DLBCL and potential implications for immune checkpoint blockade and neoantigen-based immunotherapies

Fig. 1

Immunoglobulin heavy chain analysis. a A high degree of IGHV SHM (SHMhigh) was associated with significantly better overall survival (OS) in DLBCL overall and in DLBCL lacking BCL2 rearrangement (BCL2-R) or MYC rearrangement (MYC-R). b IGHV SHMhigh was associated with significantly better OS and progression-free survival (PFS) in the training set, and significantly better OS in the BCL2-R cases of the validation set. c Short heavy chain complementarity determining region 3 (HCDR3) length was associated with significantly better OS in the germinal center B-cell-like (GCB)-DLBCL and overall DLBCL

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