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Fig. 5 | Journal for ImmunoTherapy of Cancer

Fig. 5

From: Immunoglobulin somatic hypermutation has clinical impact in DLBCL and potential implications for immune checkpoint blockade and neoantigen-based immunotherapies

Fig. 5

Prognostic and correlative analyses for light chain IGK/LV SHM. a A high degree of IGK/LV SHM (SHMhigh) was associated with significantly worse overall survival (OS) in GCB-DLBCL. b The adverse prognostic effect of IGK/LV SHMhigh in GCB-DLBCL was significant in both the training and validation sets. c IGK/LV SHMhigh was associated with higher PD-L1 expression in CD56+ natural killer cells in overall GCB-DLBCL cases and with high PD-1 expression in CD4+ T cells in the training set. d There was a negative correlation between light chain IGK/LV ongoing SHM and IGK/LV SHM. High IGK/LV ongoing SHM was associated with low CTSS mRNA expression. e High numbers (≥17) of subclones with IGK/LV ongoing SHM were associated with significantly poorer OS in DLBCL

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