Fig. 6From: Niclosamide, an antihelmintic drug, enhances efficacy of PD-1/PD-L1 immune checkpoint blockade in non-small cell lung cancerSTAT3 phosphorylation positively correlates with PD-L1 expression in tumor tissues from patients with NSCLC. a, b Representative immunohistochemical staining of PD-L1 and p-STAT3 in human NSCLC. Scale bars = 100 μm. c Percent distribution of immunotherapy treatments for included NSCLC patient population. d Linear regression analysis of p-STAT3 and PD-L1 immunohistochemical scores in a human NSCLC tissue microarray; P < 0.001, r = 0.801. e, f Kaplan-Meier plots for progression-free survival analysis by optimal cutoff value of PD-L1 and p-STAT3 immunohistochemical scores. Samples were grouped as p-STAT3 high (H-score > 3.8), p-STAT3 low (H-score < 3.8), PD-L1 high (H-score > 2.925), or PD-L1 low (H-score < 2.925)Back to article page