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Fig. 2 | Journal for ImmunoTherapy of Cancer

Fig. 2

From: Immunosuppression by monocytic myeloid-derived suppressor cells in patients with pancreatic ductal carcinoma is orchestrated by STAT3

Fig. 2

Blood-circulating MDSC enumeration in PDAC patients. a-b Flow cytometry analysis of circulating myeloid cells in whole blood of two independent cohorts of PDAC patients (b PDAC n = 21, HD = 8; c PDAC n = 23, HD = 9): monocytes (CD14+CD15), MDSC1 (CD14+IL-4Rα+), MDSC4 (CD14+HLA-DRlow/−), granulocytes (CD15+CD14), MDSC2 (CD15+IL-4Rα+) and MDSC3 (LINHLA-DRCD33+SSChigh). c Flow cytometry analysis of circulating M-MDSCs (MDSC1, CD14+IL-4Rα+; MDSC4, CD14+HLA-DRlow/−) and e-MDSCs (MDSC3, LINHLA-DRCD33+SSChigh) in PDAC patients (n = 73) compared to healthy donors (HD; n = 28). M-MDSC percentages were evaluated on frozen PBMCs, whereas e-MDSCs on the whole blood. Statistical analysis was performed by ANOVA test

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