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Fig. 2 | Journal for ImmunoTherapy of Cancer

Fig. 2

From: Tertiary lymphoid organs in the inflammatory myopathy associated with PD-1 inhibitors

Fig. 2

a-c PNAd and CD31(endothelial cells) in a control muscle without pathological change. PNAd is not visible. d-f PNAd in Case 3 showing positivity (green) in the interstitial tissue, particularly on the blood vessels (red). g-i PNAd in Case 2. The merged image demonstrates a vessel strongly positive for PNAd (green) on the endothelial cells (red). j-l CCL2 in normal muscle. No positivity was detected. m-o CCL21in Case 1. The merged image shows positive CCL21 (green) on some blood vessels (red) in the perivascular space and around the muscle fibers. p-r CCL21 in Case 3. Blood vessels (CD31 red) around a muscle fiber show positivity for CCL21

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