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Fig. 2 | Journal for ImmunoTherapy of Cancer

Fig. 2

From: TLR9 acts as a sensor for tumor-released DNA to modulate anti-tumor immunity after chemotherapy

Fig. 2

Effect of TLR9 on the anti-tumor immune response following chemotherapy. a-c TC-1 tumor-bearing wildtype or TLR9−/− mice were treated with indicated combinations of cisplatin and/or E7 peptide. a Line-graph depicting tumor growth kinetics (n = 10). b Kaplan-Meier survival analysis of mice (n = 10). c Left: Representative flow cytometry depicting the frequency of systemic E7-specific CTLs in TC-1 tumor-bearing mice (n = 5). Right: Bar graph quantification. d-f TC-1 tumor-bearing wildtype C57BL/6 or TLR9−/− mice were treated with doxorubicin and E7 peptide. d Line-graph depicting tumor growth kinetics (n = 10). e Kaplan-Meier survival analysis of mice (n = 10). f Left: Representative flow cytometry depicting the frequency of systemic E7-specific CTLs (n = 5). Right: Bar graph quantification. g-h EG7 lymphoma-bearing wildtype or TLR9−/− mice were treated with cisplatin and Ova peptide or with PBS control. g Kaplan-Meier survival analysis of mice (n = 5). h Left: Representative flow cytometry depicting the frequency of systemic Ova-specific CTLs in mice (n = 5). Right: Bar graph quantification. Significance determined by ANOVA (a-b, d-e, g), student’s t test (c, f, h). Data are represented as mean ± SD. *P < 0.01

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