Skip to main content
Fig. 4 | Journal for ImmunoTherapy of Cancer

Fig. 4

From: Tumor immune microenvironment and genomic evolution in a patient with metastatic triple negative breast cancer and a complete response to atezolizumab

Fig. 4

Characterization of Genomic Landscape Over Time. Samples collected pre- and post-atezolizumab exposure were tested with the FoundationOne® targeted NGS assay. Upper panel: genes with detected single nucleotide variants (SNV). Mutant allele frequencies (MAF) are shown for each specimen. Asterisk (*) indicates that the variant was present at a frequency below the validated reporting threshold. Light gray: predicted somatic mutations, dark gray: predicted germline mutations; Bold: predicted subclonal somatic mutations. Middle panel: genes with detected copy number alterations (CNAs). Numbers indicate the number of copies detected. Asterisk (*) indicates that low-level amplifications were detected below the validated reporting threshold of > 5 copies. No homozygous deletions were observed. Lower panel: tumor mutational burden (TMB) indicated as mutations per megabase

Back to article page