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Table 2 CAR-T cell therapy studies on prostate cancer

From: CAR-T cell therapy: a potential new strategy against prostate cancer

Publication Publication year Country Institution Setting Cell source and type Generation Costimulatory domain
Gade et al [72] 2005 USA Memorial Sloan-Kettering Cancer Center Preclinical - mice model Anti PSMA CAR-T cells First generation
Maher et al [73] 2002 USA Memorial Sloan-Kettering Cancer Center Preclinical Anti PSMA CAR-T cells Second generation CD28
Zuccolotto et al [74] 2014 Italy University of Padua Preclinical - mice model Anti PSMA CAR-T cells Second generation CD28
Ma et al [75] 2014 USA Roger Williams Med Center Preclinical - mice model Anti PSMA CAR-T cells Second generation CD28
Slovin et al [76] 2017 USA Memorial Sloan-Kettering Cancer Center Phase I NCT01140373 Autologous T Anti PSMA CAR-T cells Second generation CD28
Kloss et al [77] 2019 USA University of Pennsylvania Preclinical - mice model Anti PSMA-TGFβ insensitive CAR-T cell Second generation 4-1BB
Zhang et al [78] 2018 UK Oxford University Preclinical - mice model Anti PSMA-TGFβ insensitive CAR-T cell Second generation 4-1BB
Hassani et al [79] 2019 Iran Tehran Univ Med Science Preclinical - mice model VHH-CAR-T cell anti PSMA Second generation CD28
Priceman et al [80] 2017 USA City of Hope, Duarte Preclinical - mice model Anti PSCA CAR-T cell Second generation 4-1BB
Hillerdal et al [81] 2014 Sweden Uppsala University Preclinical - mice model Anti PSCA CAR-T cell Third generation CD28, OX-40 CD3ζ
Kloss et al [82] 2012 USA Memorial Sloan-Kettering Cancer Center Preclinical - mice model Anti PSCA/Anti PSMA CAR-T cell Third generation 4-1BB, CD28
Feldman et al [83] 2017 Germany Institute of radiopharmaceutical Cancer Research, Dresden Preclinical - mice model Anti PSCA/Anti PSMA CAR-T cell Second generation CD28
Deng et al [84] 2015 China Cancer Hospital & Institute Preclinical - mice model Anti EpCAM CAR-T cell Second generation CD28
NCT03873805 2019 USA City of Hope, Duarte Phase I Anti PSCA CAR-T cell Second generation 4-1BB
  1. Abbreviations: CAR chimeric antigen receptor, PSMA prostate-specific membrane antigen, TGFβ transforming growth factor β, PSCA prostate stem cell antigen, EpCAM epithelial cell adhesion molecules, VHH camelid nanobody