From: CAR-T cell therapy: a potential new strategy against prostate cancer
Publication | Publication year | Country | Institution | Setting | Cell source and type | Generation | Costimulatory domain |
---|---|---|---|---|---|---|---|
Gade et al [72] | 2005 | USA | Memorial Sloan-Kettering Cancer Center | Preclinical - mice model | Anti PSMA CAR-T cells | First generation | – |
Maher et al [73] | 2002 | USA | Memorial Sloan-Kettering Cancer Center | Preclinical | Anti PSMA CAR-T cells | Second generation | CD28 |
Zuccolotto et al [74] | 2014 | Italy | University of Padua | Preclinical - mice model | Anti PSMA CAR-T cells | Second generation | CD28 |
Ma et al [75] | 2014 | USA | Roger Williams Med Center | Preclinical - mice model | Anti PSMA CAR-T cells | Second generation | CD28 |
Slovin et al [76] | 2017 | USA | Memorial Sloan-Kettering Cancer Center | Phase I NCT01140373 | Autologous T Anti PSMA CAR-T cells | Second generation | CD28 |
Kloss et al [77] | 2019 | USA | University of Pennsylvania | Preclinical - mice model | Anti PSMA-TGFβ insensitive CAR-T cell | Second generation | 4-1BB |
Zhang et al [78] | 2018 | UK | Oxford University | Preclinical - mice model | Anti PSMA-TGFβ insensitive CAR-T cell | Second generation | 4-1BB |
Hassani et al [79] | 2019 | Iran | Tehran Univ Med Science | Preclinical - mice model | VHH-CAR-T cell anti PSMA | Second generation | CD28 |
Priceman et al [80] | 2017 | USA | City of Hope, Duarte | Preclinical - mice model | Anti PSCA CAR-T cell | Second generation | 4-1BB |
Hillerdal et al [81] | 2014 | Sweden | Uppsala University | Preclinical - mice model | Anti PSCA CAR-T cell | Third generation | CD28, OX-40 CD3ζ |
Kloss et al [82] | 2012 | USA | Memorial Sloan-Kettering Cancer Center | Preclinical - mice model | Anti PSCA/Anti PSMA CAR-T cell | Third generation | 4-1BB, CD28 |
Feldman et al [83] | 2017 | Germany | Institute of radiopharmaceutical Cancer Research, Dresden | Preclinical - mice model | Anti PSCA/Anti PSMA CAR-T cell | Second generation | CD28 |
Deng et al [84] | 2015 | China | Cancer Hospital & Institute | Preclinical - mice model | Anti EpCAM CAR-T cell | Second generation | CD28 |
NCT03873805 | 2019 | USA | City of Hope, Duarte | Phase I | Anti PSCA CAR-T cell | Second generation | 4-1BB |