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Fig. 2 | Journal for ImmunoTherapy of Cancer

Fig. 2

From: Nivolumab in chemotherapy-resistant cervical cancer: report of a vulvitis as a novel immune-related adverse event and molecular analysis of a persistent complete response

Fig. 2

a-c Biopsy of the vulva with lichenoid interface dermatitis: Squamous epithelium with hyper- and parakeratosis, irregular acanthosis, and dense band-like and perivascular lymphocytic infiltrate along the dermo-epidermal junction as well as intraepithelial lymphocytic infiltrate. Scattered necrotic keratinocytes (original magnification a 40x, b 100x, c, 200x). e-f Immunohistochemistry for T cell markers CD3, CD4, and CD8: Intraepithelial T cells predominantly express CD8 (original magnification e, f 100x)

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