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Fig. 3 | Journal for ImmunoTherapy of Cancer

Fig. 3

From: Nivolumab in chemotherapy-resistant cervical cancer: report of a vulvitis as a novel immune-related adverse event and molecular analysis of a persistent complete response

Fig. 3

Microarray data analysis: a Region of interest within UMAP plot of the top 25′000 differentially methylated sites in the genome reveals that the current case (magenta arrow) does not fall into the centre of classical cervical squamous cell carcinomas (yellow) but overlaps with the methylation classes of squamous cell carcinomas of various origins (other colors); brown dots at bottom: bladder cancer. b, c Copy number profiles of tumour-derived DNA, calculated with R/conumee from methylation array data; b this case; c typical copy number profile of cervical squamous cell carcinoma (from TCGA reference cohort)

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