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Fig. 5 | Journal for ImmunoTherapy of Cancer

Fig. 5

From: Domatinostat favors the immunotherapy response by modulating the tumor immune microenvironment (TIME)

Fig. 5

Combination therapy of domatinostat with PD-1 and LAG3 blockade significantly increases antitumoral responses. C38 tumor model as in Fig. 4; animals were treated with 60 mg/kg domatinostat once daily (a, b) or 20 mg/kg domatinostat twice daily (c, d); anti-PD-1 and anti-LAG3 antibodies were administered at 10 mg/kg as detailed in the Methods (n = 20 per group). a, Tumor volumes (mean + SD) over time. b, Kaplan-Meier event-free survival plots. An event was defined as a tumor volume of 1500 mm3. End of study was day 70. c, Tumor volumes at day 27; response was defined as tumor regression below a volume of 100 mm3 (dotted line). d, Changes in tumor volumes over time for each individual animal and the number of responding animals out of the total for treatment regimens corresponding to (c); arrows indicate two animals with an incipient tumor regression after initial progress. c, Box and whiskers (min, max) showing all points. a, c, P-value: Kruskal-Wallis test; Dunn’s multiple comparison (d27) to vehicle. b, P-value: log-rank (Mantel-Cox) test, comparison to vehicle. *, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001; ns, not significant

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