Fig. 6

Combination therapy of domatinostat with the agonistic anti-4-1BB antibody significantly increases antitumoral responses. C38 tumor model as in Figs. 4 and 5; animals were treated with 20 mg/kg domatinostat twice daily; agonistic anti-4-1BB antibody was administered at 10 mg/kg as detailed in the Methods (n = 20 per group). a, Tumor volumes at day 27; response was defined as tumor regression below a volume of 100 mm³ (dotted line). b, Changes in tumor volume over time for each individual animal and for responding animals out of the total for each treatment regimen listed in (a). a, Box and whiskers (min, max) showing all points, P-value: Kruskal-Wallis test; Dunn’s multiple comparison (d27) to vehicle. *, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001; ns, not significant