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Fig. 7 | Journal for ImmunoTherapy of Cancer

Fig. 7

From: Domatinostat favors the immunotherapy response by modulating the tumor immune microenvironment (TIME)

Fig. 7

Domatinostat increases IFN-γ, APM/MHC and PD-1 therapy response scores in biopsies of domatinostat-treated melanoma patients. Six patients (P01-P06) with advanced cutaneous melanoma treated with 100 mg domatinostat once daily in a phase I/II clinical trial (SENSITIZE trial: NCT03278665) were subjected to biopsy of tumor lesions before (screen, baseline) and after 14 days of treatment (C01D14) for analysis of gene expression (RNA-seq). a, Baseline expression scores (mean log2(TPM + 0.001)) for selected gene sets per patient. b-f, Expression changes after 14 days of domatinostat monotherapy (C01D14) shown as log2 fold change (FC) from the baseline score for APM/MHC genes (b), cytolytic activity genes (c), IFNG (d), the 10-gene IFN-γ-related signature [5] (e) and the pembrolizumab response (RE) signature [5] (f)

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