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Table 1 Lab test results

From: Seronegative autoimmune autonomic ganglionopathy from dual immune checkpoint inhibition in a patient with metastatic melanoma

Lab

Result

Normal range

Aldosterone

13 ng/dL

3–16 ng/dL

Plasma renin activity

0.51 ng/mL/h

0.25–5.82 ng/mL/h

TSH

3.500 uLU/mL

0.300–4.200 uLU/mL

Free T4

1.12 ng/dL

0.8–1.80 ng/dL

Total T3

69.9 ng/dL (slightly low likely due to impaired T4 to T3 conversion in illness)

79–149 ng/dL

Prolactin

20.1 ng/mL (mildly elevated thought to be from chronic prochlorperazine use)

0–14.0 ng/mL

FSH

7.1 mU/mL

1–12 mU/mL

LH

7.1 mU/mL

1.6–9.6 mU/mL

AM cortisol

multiple unstimulated cortisol levels as high as 22.3

7–25 μg/dL

Testosterone total

334 ng/dL

250–1100 ng/dL

Free testosterone

60.7 pg/mL

35–155 pg/mL

Sex hormone binding globulin

61 nmol/L

22–77 nmol/L

ANA by IFA

< 1:80

< 1:80

B12

1187 pg/mL

180–914 pg/mL

Lyme antibodies

0.43 LI

< 0.90 LI

Treponema pallidum antibody

Nonreactive

nonreactive

Total CK

61 U/L

24–195 U/L

HIV

Negative

Negative

Anti-Neuronal Nuclear Ab, Type 1, 2, 3

Negative

< 1:240 titer

Anti-Glial Nuclear Ab, Type 1

Negative

< 1:240 titer

Purkinje Cell Cytoplasmic Ab Type 1, 2, Tr

Negative

< 1:240 titer

Amphiphysin Antibody

Negative

< 1:240 titer

CRMP-5, IgG

Negative

< 1:240 titer

Striational Antibody

Negative

< 1:120 titer

P/Q-Type Calcium Channel Ab

0.00

<=0.02 nmol/L

N-Type Calcium Channel Ab

0.00

<=0.03 nmol/L

ACh Receptor (Muscle) Binding Ab

0.00

<=0.02 nmol/L

AChr Ganglionic Neuronal Antibody

0.00

<=0.02 nmol/L

Neuronal (V-G) K+ Channel (CASPR2, LG11) Antibody

0.01

<=0.02 nmol/L

Anti GAD-65 Ab

0.00

<=0.02 nmol/L