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Table 1 Expression levels of 13 features regarding 9 immune checkpoint markers in nasopharyngeal carcinoma

From: Development and validation of an immune checkpoint-based signature to predict prognosis in nasopharyngeal carcinoma using computational pathology analysis

No. of NPC Patients (%) with Expression Above the Cutoff Value

Marker

Median

>  1%

>  5%

>  25%

>  50%

TAIC expression

 PD-L1

12.97

201 (97)

151 (73)

59 (28)

16 (8)

 B7-H3

26.13

196 (94)

175 (84)

105 (50)

50 (24)

 B7-H4

22.06

205 (99)

195 (94)

90 (43)

21 (10)

 IDO-1

20.75

206 (99)

187 (90)

83 (40)

14 (7)

 LAG3

5.55

197 (95)

109 (52)

15 (7)

5 (2)

 VISTA

12.46

205 (99)

169 (81)

30 (14)

3 (1)

 TIM3

2.75

183 (88)

62 (30)

0 (0)

0 (0)

 ICOS

26.21

207 (100)

204 (98)

111 (53)

9 (4)

 OX40

19.95

208 (100)

192 (92)

80 (38)

24 (12)

TC expression

 PD-L1

10.44

191 (92)

136 (65)

49 (24)

22 (11)

 B7-H3

7.01

165 (79)

115 (55)

50 (24)

19 (9)

 B7-H4

13.41

200 (96)

162 (78)

57 (27)

13 (6)

 IDO-1

7.66

195 (94)

131 (63)

23 (11)

6 (3)

  1. Abbreviations: TC tumour cell, TAIC tumour-associated immune cell