Fig. 1
From: Distinct tumor microenvironments of lytic and blastic bone metastases in prostate cancer patients
Distinct histopathology of blastic and lytic prostate cancer in bone. a, b Hematoxylin and Eosin (H&E) staining highlight the appearance of prostate cancer in bone with lytic type metastases that have destructive appearance at bone, while blastic metastases indicate new bone and mineralization with excess matrix and collagen buildup. c, d CD68 immunohistochemistry (IHC) can identify macrophages as well as other cell types including osteoclasts (black arrow). e, f T cells are visualized for their location by IHC for CD3 which indicate that diverse sets of T cells exist in both lytic and blastic metastases. Scale Bars = 500 μm for low power and 100um for high power and IHC