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Fig. 2 | Journal for ImmunoTherapy of Cancer

Fig. 2

From: IL-17 inhibits CXCL9/10-mediated recruitment of CD8+ cytotoxic T cells and regulatory T cells to colorectal tumors

Fig. 2

IL-17 blocks the accumulation of CD8+ T lymphocytes starting from early stage CRC. a Immunostaining of colon tumors from 5-month-old Cdx2-Cre+/ApcF/+ mice that were heterozygous (+/−) or null (−/−) for Il17ra. Scale bar = 100 μm. b Statistics for the percentages of CD8+ cells shown in a. n = 8. c-e: Cdx2-Cre-ERT2+/ApcF/F mice that were Il17ra+/− or Il17ra−/− were sacrificed 5 weeks after tamoxifen-induced Apc ablation, and their MLN (c and d) and tumors (c, d, and e) were subjected to flow cytometry (c and e, n = 4 for Il17ra+/−, 10 for Il17ra−/−) and q-RT-PCR (d, n = 5 for MLN, 11 for tumor) analyses. Data represent means ± S.E.M. *p < 0.05 in Students’ t test

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