Fig. 3

SPEAR T-cell therapy alters cellular infiltrate in tumor microenvironment. a Markers associated with immune cells and their function were evaluated at pre-infusion (red), and post- infusion at week 8 (blue) or beyond week 8 (grey) by IHC and plotted as a percentage of marker area within tumor area. Statistical significance in marker positivity between time points was determined by a two-way ANOVA test. b Immune marker expression in a representative region of pre- and post- infusion biopsies in one patient with increased leukocyte infiltration at week 8, and in another patient with minimal changes at >week 8 time point. Scale bar = 50 μm