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Fig. 2 | Journal for ImmunoTherapy of Cancer

Fig. 2

From: Inflammatory signatures for quick diagnosis of life-threatening infection during the CAR T-cell therapy

Fig. 2

“Double Peaks of IL-6” as a sign for grade 4–5 infection a-b The peak level of serum IL-6 and ferritin during the period of grade 1–3 infection, grade 4–5 infection, grade 1–2 CRS and grade 3–5 CRS. Data were statistically analyzed by Mann-Whitney tests; ns, not significant; *, P < 0.05; ***, P < 0.001. c-d Dynamic changes of serum IL-6 and ferritin in two patients with grade 4–5 infection. The arrows represent the peaks of IL-6; In the “double peaks of IL-6”, the first peak appeared during CRS period and the second peak took place during the period of grade 4–5 infection. In the absence of the “double peaks of IL-6”, the only peak of IL-6 occurred during the period of concurrent grade 4–5 infection and CRS. e The frequency of “double peaks of IL-6” in patients with grade 4–5 infection (N = 11). f The occurrence time of “double peaks of IL-6” relative to the reporting time of positive bacterial culture in 7 patients with grade 4–5 bacterial infection

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