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Fig. 3 | Journal for ImmunoTherapy of Cancer

Fig. 3

From: Inflammatory signatures for quick diagnosis of life-threatening infection during the CAR T-cell therapy

Fig. 3

Prediction model for grade 4–5 infection. a Relative level of serum 70 biomarkers (versus healthy donors) was shown by a heatmap after unsupervised clustering analysis. b The biomarkers that showed statistical differences in serum levels between patients with CRS and those with grade 4–5 infection (IL-8, EPO, IL-13, IFN-γ, IL-1β, IL-31, IL-1RA, IL-21). The data were statistically analyzed by Mann-Whitney tests; *, P < 0.05; ***, P < 0.001. c-d. To assess the prediction model of three-cytokines (IL-8, IFN-γ and IL-1β), ROC analysis was performed in training group and validation group

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