Skip to main content
Fig. 1 | Journal for ImmunoTherapy of Cancer

Fig. 1

From: Functional characterization of the selective pan-allele anti-SIRPα antibody ADU-1805 that blocks the SIRPα–CD47 innate immune checkpoint

Fig. 1

SIRPαV1, SIRPαV2, and SIRPαV8 are the main SIRPα variants in human. a The SIRP family of paired receptors comprises inhibitory (SIRPα), activating (SIRPβ) and non-signaling (SIRPγ) members. Mϕ, macrophage; DC, dendritic cell; Mono, monocyte; PMN, polymorphonuclear neutrophils; NK cell, natural killer cell; NKT cell, natural killer T-cell. b The human SIRPA reference allele hSIRPαV1 is dominant in Europeans (EUR), Africans (AFR), Ad Mixed American (AMR) and South Asians (SAS), whereas hSIRPαV2 dominates in East Asians (EAS). Indicated percentages specify the SIRPA allele frequency of hSIRPαV1, hSIRPαV2 and hSIRPαV8. Not annotated, frequency > 3; Others, frequency < 3. c Sequence alignment of hSIRPαV1, hSIRPαV2, and hSIRPαV8 proteins (derived from [26]) demonstrates the differences within the CD47-binding extracellular Ig-like V-type (IgV) domain

Back to article page