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Fig. 2 | Journal for ImmunoTherapy of Cancer

Fig. 2

From: Functional characterization of the selective pan-allele anti-SIRPα antibody ADU-1805 that blocks the SIRPα–CD47 innate immune checkpoint

Fig. 2

hSIRPα.40A is a CD47 blocking antibody with a unique epitope. a hSIRPα.40A shows pan-allele anti-hSIRPα binding, cross-reacts with hSIRPγ, and lacks appreciable hSIRPβ1 binding, thereby differentiating from allele-specific (anti-hSIRPαV1) and pan-hSIRP antibodies (KWAR23 [30]). b hSIRPα.40A blocks CD47 binding to hSIRPαV1 and hSIRPαV2-expressing U-937 and THP-1 AML cell lines. (a, b: Mean ± SD; representative of n = 2 is shown)

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