Table 1 hSIRPαV1 binding affinities of parental, chimeric, and humanized hSIRPα.40A variants measured on Octet AR2G biosensor. (Values represent Mean ± SD; n = 2–4 repeats)
Antibody | KD (M) | ka(1/Ms) | kdis(1/s) |
|---|---|---|---|
hSIRPα.40A | 12.1E-09 ± 3.7E-09 | 4.4E+ 05 ± 1.1E+ 05 | 5.6E-03 ± 3.0E-03 |
hSIRPα.40.C2 | 15.4E-09 ± 8.5E-11 | 4.4E+ 05 ± 9.7E+ 04 | 6.8E-03 ± 1.5E-03 |
ADU-1805 | 11.0E-09 ± 1.85E-09 | 3.4E+ 05 ± 8.7E+ 04 | 3.8E-03 ± 1.4E-03 |