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Table 1 hSIRPαV1 binding affinities of parental, chimeric, and humanized hSIRPα.40A variants measured on Octet AR2G biosensor. (Values represent Mean ± SD; n = 2–4 repeats)

From: Functional characterization of the selective pan-allele anti-SIRPα antibody ADU-1805 that blocks the SIRPα–CD47 innate immune checkpoint

AntibodyKD (M)ka(1/Ms)kdis(1/s)
hSIRPα.40A12.1E-09 ± 3.7E-094.4E+ 05 ± 1.1E+ 055.6E-03 ± 3.0E-03
hSIRPα.40.C215.4E-09 ± 8.5E-114.4E+ 05 ± 9.7E+ 046.8E-03 ± 1.5E-03
ADU-180511.0E-09 ± 1.85E-093.4E+ 05 ± 8.7E+ 043.8E-03 ± 1.4E-03