From: Functional characterization of the selective pan-allele anti-SIRPα antibody ADU-1805 that blocks the SIRPα–CD47 innate immune checkpoint
Antibody
KD (M)
ka(1/Ms)
kdis(1/s)
hSIRPα.40A
12.1E-09 ± 3.7E-09
4.4E+ 05 ± 1.1E+ 05
5.6E-03 ± 3.0E-03
hSIRPα.40.C2
15.4E-09 ± 8.5E-11
4.4E+ 05 ± 9.7E+ 04
6.8E-03 ± 1.5E-03
ADU-1805
11.0E-09 ± 1.85E-09
3.4E+ 05 ± 8.7E+ 04
3.8E-03 ± 1.4E-03