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Table 2 Study setup of the ADU-1805 non-GLP pilot toxicity study in 5–7 years old cynomolgus monkeys. A single dose of ADU-1805 or vehicle was administered i.v. for a duration of 15 min. Vehicle refers to the antibody formulation buffer: 10 mM L-Histidine pH 5.5 containing 0.1 M sodium chloride

From: Functional characterization of the selective pan-allele anti-SIRPα antibody ADU-1805 that blocks the SIRPα–CD47 innate immune checkpoint

GroupTreatmentDoseAnimals
1Vehicle1 male / 1 female
C2ADU-18050.3 mg/kg1 male / 1 female
3ADU-18053 mg/kg1 male / 1 female
4ADU-180530 mg/kg1 male / 1 female