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Table 2 Study setup of the ADU-1805 non-GLP pilot toxicity study in 5–7 years old cynomolgus monkeys. A single dose of ADU-1805 or vehicle was administered i.v. for a duration of 15 min. Vehicle refers to the antibody formulation buffer: 10 mM L-Histidine pH 5.5 containing 0.1 M sodium chloride

From: Functional characterization of the selective pan-allele anti-SIRPα antibody ADU-1805 that blocks the SIRPα–CD47 innate immune checkpoint

Group

Treatment

Dose

Animals

1

Vehicle

–

1 male / 1 female

C2

ADU-1805

0.3 mg/kg

1 male / 1 female

3

ADU-1805

3 mg/kg

1 male / 1 female

4

ADU-1805

30 mg/kg

1 male / 1 female

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